X BOX BINDING

[Y]

1 : P17861 . X BOX BINDING PROT...[gi:139787]PubMed, Related Sequences
LOCUS       XBP1_HUMAN    260 aa                    PRI       01-JUN-1994
DEFINITION  X BOX BINDING PROTEIN-1 (XBP-1) (TREB5 PROTEIN).
ACCESSION   P17861
PID         g139787
VERSION     P17861  GI:139787
DBSOURCE    swissprot: locus XBP1_HUMAN, accession P17861;
             class: standard.
             created: Nov 1, 1990.
             sequence updated: Nov 1, 1990.
             annotation updated: Jun 1, 1994.
             xrefs: gi: 184485, gi: 306893, gi: 287644, gi: 287645, gi: 105867,
             gi: 94224
             xrefs (non-sequence databases): HSSP P05412, TRANSFAC T00902, MIM
             194355, PFAM PF00170, PROSITE PS00036
KEYWORDS    Transcription regulation; DNA-binding; Nuclear protein.
SOURCE      human.
   ORGANISM  Homo sapiens
             Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
             Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 260)
   AUTHORS   Liou,H.C., Boothby,M.R., Finn,P.W., Davidon,R., Nabavi,N.,
             Zeleznik-Le,N.J., Ting,J.P. and Glimcher,L.H.
   TITLE     A new member of the leucine zipper class of proteins that binds to
             the HLA DR alpha promoter
   JOURNAL   Science 247 (4950), 1581-1584 (1990)
   MEDLINE   90208323
   REMARK    SEQUENCE FROM N.A.
REFERENCE   2  (residues 1 to 260)
   AUTHORS   Yoshimura,T., Fujisawa,J. and Yoshida,M.
   TITLE     Multiple cDNA clones encoding nuclear proteins that bind to the
             tax-dependent enhancer of HTLV-1: all contain a leucine zipper
             structure and basic amino acid domain
   JOURNAL   EMBO J. 9 (8), 2537-2542 (1990)
   MEDLINE   90316112
   REMARK    SEQUENCE FROM N.A.
COMMENT     -------------------------------------------------------------------
             This SWISS-PROT entry is copyright. It is produced through a
             collaboration between the Swiss Institute of Bioinformatics and
             the EMBL outstation - the European Bioinformatics Institute.
             The original entry is available from http://www.expasy.ch/sprot
             and http://www.ebi.ac.uk/sprot
             ------------------------------------------------------------------.
             [FUNCTION] BINDS TO THE HLA DR-ALPHA PROMOTER. MAY ACT AS A
             TRANSCRIPTION FACTOR IN B-CELLS. BINDS TO THE TAX-RESPONSIVE
             ELEMENT (TRE) OF HTLV-I.
             [SUBCELLULAR LOCATION] NUCLEAR.
             [SIMILARITY] TO OTHER BZIP PROTEINS.
FEATURES             Location/Qualifiers
      source          1..260
                      /organism="Homo sapiens"
                      /db_xref="taxon:9606"
                      1..260
      Protein         1..260
                      /product="X BOX BINDING PROTEIN-1"
      Region          33..34
                      /region_name="Conflict"
                      /note="AR -> GQA (IN REF. 2)."
      Site            71..93
                      /site_type="dna-binding"
                      /note="BASIC MOTIF."
      Region          97..125
                      /region_name="Domain"
                      /note="LEUCINE-ZIPPER."
ORIGIN
         1 mvvvaaapnp adgtpkvlll sgqpasaaga paarlplmvp aqrgaspeaa sgglpqarkr
        61 qrlthlspee kalrrklknr vaaqtardrk karmseleqq vvdleeenqk lllenqllre
       121 kthglvvenq elrqrlgmda lvaeeeaeak gnevrpvags aesaalrlra plqqvqaqls
       181 plqnispwil avltlqiqsl iscwafwttw tqscssnalp qslpawrssq rstqkdpvpy
       241 qppflcqwgr hqpswkplmn
//