[AGL] Fw: Old miracle drug rediscovered
Michele Mason
yaya.m at earthlink.net
Tue Oct 31 19:18:05 EST 2006
Bill, Sounds very good and somewhere in here is where to get it? Too
tired to search. Thank-you for meaningful help as always mm
On Oct 31, 2006, at 1:58 PM, Bill Irwin wrote:
> Note: I am fowarding this on to your list Mike because I think it is
> some thing everyone should know about. Also, I think Wayne should be
> taking this and I would be interested in hearing what Gerry would have
> to say about this.
>
>
>
>
> The upcoming memorial to Billy Jim makes me think that some things can
> be done to protect against cancer. With this thought in mind I would
> like to introduce to the ghetto folks a nutraceutical that can do much
> to enhance the immune system and to protect us against cancer and a
> host of other problems. You may not have heard of it before as
> knowledge of its benefits is not that old and it is not that available
> in the stores. That substance is Beta Glucan. It is found in oat
> meal and is responsible for all the advertising proclaiming the
> healthful aspects of oats which is all true. It is also found in
> other foods but in lesser amounts. It is also found in abundance in
> the Japanese Maitake mushrooms which have been used to prevent and
> treat cancer for a long time. The beta glucan you buy in health food
> stores has three major sources - extracted from oats, extracted from
> the Maitake mushroom, or made from the breakdown of the cell walls of
> a nutritional yeast. As far as I can tell they are all about the
> same. This nutraceutical has so many health benefits that I think
> everyone should know about it and be taking it for their own health
> and protection against cancer and other infections. So I am going to
> give the complete low-down on beta glucan and why you should be using
> it.
>
> This is important so pay attention. The reading list is difficult but
> worth the effort.
>
> Beta glucan is a polysaccharide (long chain sugar) molecule with
> important branches at certain positions. You may see it labeled as
> Beta-1,3/1,6 -D-Glucan - meaning it has branches at the 1,3 position
> and the 1,6 position. It plays a very critical role in the immune
> system. Macrophages, the white blood cells that go around the body
> and attacks germs, cancers, and foreign antigens, they can destroy
> cancer cells and eat them for breakfast, same for germs. Macrophages
> have attachment sites on the outside of the cells for beta glucans.
> The more beta glucan that attaches to the macrophages the more
> aggressive they become in attacking cancers and germs. They also
> produce more tumor necrosis factor, TNF, which is a compound that can
> kill cancer cells. They also produce more Interleukin-2 which
> activates and stimulates the growth of immune cells, most importantly
> T-Cells, but also Natural Killer Cells , both of which are capable of
> destroying cancer cells directly. Macrophages are some of the first
> white blood cells to appear at the site of a physical wound as part of
> their job is to also eat up dead cell tissues and catch germs that
> enter the wound. Beta glucan is probably the best stimulant of the
> immune system that you could find. Some other cells have attachment
> points for beta glucan, most notably dermal fibroblast cells which do
> much of the work in making new skin - more on this later.
>
> For a good paper on immune system deficiencies, their causes,
> symptoms, what can be done about it and the use of beta glucan see
> this reference - http://www.immunocorp.com/ca/research.pdf A lot of
> good information and you should read it, moderately difficult. It
> makes the case for immune system repair.
>
> Much is made of the use of beta glucan to treat cancer. Countless
> studies have been made and all say that beta glucan is an aid to
> cancer treatment. The use of mushrooms to treat cancer has long been
> known in Asia. Here is a good paper on the use of mushroom beta
> glucans to treat cancer -
> http://www.thorne.com/altmedrev/fulltext/cancer5-1.html Beta glucan
> when taken in conjunction with chemo agents enhance the effects of
> chemo and reduce its bad effects. It's 1+1= 2.5 or more and you get
> less sick from the chemo. Numerous case histories also show where
> beta glucan cured the cancer and in most every case the cancer was
> slown down. Works best with chemo but can work on a daily basis to
> prevent the rise of cancer cells at a very early stage. Here is a
> report on the use of mushroom extracts to treat cancer patients with
> many case histories -
> http://www.thorne.com/pdf/journal/7-3/maitake_md_fraction.pdf
>
> Another good paper is this one on the use of mushroom beta glucans to
> treat cancer and also discusses beta glucan to treat diabetes,
> hypertension, cholesterol, and a few other conditions.
> http://www.thorne.com/pdf/journal/6-1/maitake_mxtract.pdf
>
> You have seen countless ads on TV about how farmer John's oat cereal
> is the cereal for healthy hearts. It will reduce cholesterol, and
> blood pressure which is all true. Farmer John didn't tell you that you
> would have to eat 2 or 3 bowls three times a day to get a therapeutic
> dose to treat a condition, but as a preventative measure it is a good
> place to start. Many studies have been made and they all show that
> beta glucan from oat meal will lower cholesterol and blood pressure
> over time. The reductions are not great but for many people it could
> mean the difference between a problem and being OK. If you need
> significant improvements quickly due to a health threat the
> pharmaceutical will give stronger action but with more side effects.
> The higher the beta glucan content the bigger the improvement. See
> the links below for references to hypertension and cholesterol studies
> that have been done.
>
> If you have type 2 diabetes beta glucan may be of some help. Several
> studies have been made on the effect of beta glucan on this type of
> diabetes and they all show that you can expect a decline in blood
> sugar and blood insulin. I am not an expert in diabetes but I would
> think that this might be of some help in reducing symptoms and long
> term side effects of type 2 diabetes. The same effect of lowering
> blood sugar and insulin also works on people who have normal sugar
> metabolism meaning that it may help people that are in danger of
> developing type 2 diabetes. This is not a cure of diabetes, only a
> help in dealing with the problem. See the reference links below for
> results of these experiments.
>
> In other promising studies beta glucan was given to patients that were
> to have high risk abdominal surgeries to see if it could prevent later
> complications. Patients who received beta glucan treatment prior to
> surgeries have fewer infections, less server infections, and fewer
> post operative complications resulting in shorter stays in intensive
> care units. One study reported a 39% decrease in infections and
> deaths in patients who received beta glucan. These results are
> supported in studies where rats given beta glucan and then had
> experimental wounds and surgeries had faster wound healing, the wounds
> developed higher tensile strength earlier, and in many case prevented
> infections in rats. The treated rats had a much higher survival rate
> and fewer complications. If you are going to have a major surgery you
> should start taking beta glucan about a week before surgery and
> continue until full recovery. I can't help to think that Clark Santos
> might still be here if he had been taking this supplement prior to his
> emergency room trip. Once again, see the references below.
>
> One of the more interesting aspects of beta glucan is its activity in
> regenerating skin. It can stimulate dermal fibroblasts to make more
> collagen which will make skin a little thicker and help to erase fine
> lines and wrinkles. Numerous studies have shown that beta glucan can
> improve wound healing, make the wound healing process stronger and
> faster. Thicker skin and fewer wrinkles sounds like something that
> the older ghetto residents might be interested in. It was also of
> some interest to the cosmetics industry and they did a scientific
> study of the question and found that beta glucan applied to the skin
> can penetrate the skin and stimulate the fibroblast to make more
> collagen and the result is improved skin condition with fewer
> wrinkles. Their study has microscopic proof of its action and data to
> support the claim to improved condition. Their study was based on a 8
> week treatment with beta glucan so it is not a quick fix.
>
> International Federation of Societies of Cosmetic Chemists report:
> http://www.ceapro.com/pdfs/ifscc.pdf
>
> Oat (1,4; 1,3) beta-glucan is a natural active ingredient offering
> significant performance enhancing properties for personal care
> applications. Our studies have shown that the molecule, despite its
> considerable molecular weight, is able to enter the stratum corneum
> and epidermis and penetrate deep into the dermis. The observed effects
> of beta-glucan on tissue restructuring and wrinkle reduction are most
> likely effects mediated by fibroblast stimulation and collagen
> deposition in the dermis. These unique properties make oat beta-glucan
> a promising and effective ingredient for cosmetics.
>
> I have been taking it for about 2 months and have noticed an
> improvement in my skin similar to the cosmetics industry report. I
> also credit it with curing a skin condition that I had. It seems to
> me that oral intake has the same skin improvement effects and does all
> the other good things that beta glucan can do so I think that is the
> best route. Some cosmetic products are already appearing on the
> market with beta glucan. Or, maybe you can have your lover massage
> you every night with hot oat meal.
>
> In summary:
>
> WHAT CAN BETA GLUCAN DO FOR YOU
> Strengthen your immune system by filling attachment points on
> macrophages thereby making them more aggressive
> Enables your immune system to better kill cancer cells
> Enables your immune system to better kill germs
> Slows the growth of cancers and in a few exceptional cases has cured
> cancers
> Works with chemo to make it stronger and reduces side effects from
> chemo
> Will give modest reductions in cholesterol
> Will give modest reductions in hypertension
> Type 2 diabetics may have lower glucose and insulin levels
> Surgery patients have fewer deaths, infection, and complications
> All wounds heal faster, better, and stronger
> Reduces fine lines in skin
> Makes your skin look younger
> Now, can anybody find some negative in this list? What we are talking
> about is some extract from oat meal. Oat meal is not a dangerous
> substance, I did not see any report on side effects in the many
> reports I have read on this substance. You need less than a 1/2 gram
> of this oat concentrate a day to get most of these protective effects,
> much more if you are headed to the operating room or have active
> cancer.
>
> About the dosage: For maintenance from 200-400 mg a day. I am taking
> 200 a day but think I could use a little more so I plan on going to
> 300 mg a day. For pre-operative protection take 1500 mg a day for a
> week before, then 500mg a day until you feel that you recovered
> completely from the surgery, then back to maintenance dose. For
> active cancer 1500 mg or more plus a complete set nutraceuticals aimed
> at fighting cancer, there are several good books on this subject.
> Vitamin D is involved with beta glucan and the immune system so you
> need to be sure you have enough - take 400-800 IU depending on your
> diet and how much time you spend in the sun.
>
> Why I am writing this letter: I am tired of hearing about Billy Jim,
> Clark Santos, Jaxon, just to name a few of the recent ones, who could
> have had their lives extended or maybe even found cures if they only
> had known about this simple substance. Now I have passed the
> information on to all of you and you can no longer plead ignorance.
> Please take care of yourself dear folk.
> Aloha,
> Ewie
>
> ******************************
>
> The references: These are mostly in the form of abstracts which are
> difficult to read as the whole research project is condensed in one
> paragraph. Generally the first sentence or two has the theses and the
> last sentence the results and a lot of big words in between.
>
> Hypertension
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=7956987&dopt=Abstract
> lowered cholesterol and LDL but not HDL
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=11978262&dopt=Citation
> RESULTS: The oat cereal (cereal enriched with beta glucan -
> 5.52%) group experienced a 7.5 mm Hg reduction in SBP (P <.01) and a
> 5.5 mm Hg reduction in DBP (P <.02), while there was virtually no
> change in either SBP or DBP in the control group. In the oat cereal
> group, a trend was observed for a lower total insulin response to a
> glucose load, suggesting improved insulin sensitivity. However, this
> could not be confirmed using estimates from the Bergman Minimal Model,
> perhaps because of our small sample size. The oats group experienced a
> significant reduction in both total cholesterol (9%) and low-density
> lipoprotein cholesterol (14%). CONCLUSIONS: The addition of oat
> cereals to the normal diet of patients with hypertension significantly
> reduces both SBP and DBP. Soluble fiber-rich whole oats may be an
> effective dietary therapy in the prevention and adjunct treatment of
> hypertension.
>
> http://intl.jacn.org/cgi/content/abstract/16/1/46
> Effect of beta-glucan level in oat fiber extracts on blood lipids in
> men and women
> Total cholesterol levels after the higher beta-glucan extract diet
> were significantly lower than those after the low beta-glucan diet.
> CONCLUSIONS: Beneficial reduction of cholesterol was obtained with
> modest amounts of oat extract incorporated into the diet. A
> significant dose response due to beta-glucan concentration in the oat
> extract was observed in total cholesterol levels.
>
> Diabetes
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=8033532&dopt=Citation
> A diet rich in beta-glucan may therefore be of benefit in the
> regulation of postprandial plasma glucose levels in subjects with Type
> 2 diabetes.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=8948386&dopt=Citation
> Oat bran concentrate bread products improve long-term control of
> diabetes: a pilot study. CONCLUSIONS: The well-accepted oat bran
> concentrate bread products improved glycemic, insulinemic, and
> lipidemic responses.
>
>
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=11874441&dopt=Citation
> Effects of a water-soluble extract of maitake mushroom on circulating
> glucose/insulin concentrations in KK mice. CONCLUSIONS: FXM, a
> natural extract obtained from maitake mushroom, favourably influences
> glucose/insulin metabolism in insulin-resistant KK mice. The lowering
> of both circulating glucose and insulin concentrations suggests that
> FXM works primarily by enhancing peripheral insulin sensitivity.
>
> Cancer
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=10851301&dopt=Citation
> A bioactive beta-glucan from the Maitake mushroom has a cytotoxic
> effect, presumably through oxidative stress, on prostatic cancer cells
> in vitro, leading to apoptosis.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=8575861&dopt=Citation
> In the established tumor model, beta glucan + BsAb reduced the
> incidence of s.c. tumors as compared with control, with BsAb alone and
> with beta glucan alone. It also prolonged survival of tumor-bearing
> mice compared with control, BsAb alone and beta glucan alone. We
> conclude that T cells can be activated in vivo by beta glucan and
> retargeted with F(ab')2 BsAb.
>
> Surgery
> http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1234447
> PGG-glucan is safe and appears to be effective in the further
> reduction of the morbidity and cost of major surgery.
>
> http://archsurg.ama-assn.org/cgi/content/abstract/134/9/977
> Conclusion Perioperative administration of PGG-glucan reduced serious
> postoperative infections or death by 39% after high-risk noncolorectal
> operations.
>
> http://www.springerlink.com/content/egx2ddc85e7fj98t/
> Inguinal hernia repair with beta glucan-coated mesh: results at
> two-year follow up - hernia repair with beta-glucan coated mesh has a
> low recurrence rate. Incidence of chronic pain is low. The situation
> is in relationship with a lightweight and smooth mesh of polypropylene
> and the role of oat beta glucan optimizing the healing and inclusion
> of the mesh into the tissues.
>
> Wound healing
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
> cmd=Retrieve&db=PubMed&list_uids=9012425&dopt=Citation
> These data indicate that macrophage modulation with glucan phosphate
> will increase tensile strength in experimental colon and skin wounds.
> In addition, we observed a positive correlation between glucan
> phosphate treatment, wound tensile strength, and collagen
> biosynthesis.
>
> Skin
> http://www.blackwell-synergy.com/links/doi/10.1046/j.1524
> -475X.2002.10804.x/abs/
> Glucan stimulates human dermal fibroblast collagen biosynthesis
> through a nuclear factor-1 dependent mechanism
>
>
> Protection against infection:
>
> http://www.blackwell-synergy.com/doi/abs/10.1111/j.1574
> -695X.2000.tb01420.x
> The data demonstrate that SSG administered systemically protects
> against pneumococcal infection in mice.
>
> http://www.springerlink.com/content/k35n277mq8680340/
> Conclusions In this rat model of intra-abdominal sepsis
> <xxlarge946.gif>-glucan treatment partially protected against
> secondary lung injury, decreased lung hemorrhages, and lung
> neutrophilia. These results suggest that <xxlarge946.gif>-glucan
> protects against sepsis-associated lung
> damage.<xxlarge946.gif><xxlarge946.gif>
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